1375. Validation of a Syndromic Surveillance Query for Lyme Carditis – New York, 2017-2021

Abstract Background Lyme carditis is a rare and potentially fatal manifestation of disease. Although disease nationally notifiable, data on specific clinical manifestations are not collected systematically. We sought to use novel syndromic surveillance query identify patients with in New York State (excluding City) during 2017-2021. Methods Using the National Syndromic Surveillance Program’s BioSense Platform, we developed using combination diagnosis codes chief complaint terms emergency department visits related carditis. systematically reviewed abstracted key information each identified individual medical record through York’s regional health exchange system, requesting supplemental records when needed. Two physicians independently assigned case status (confirmed; probable; case) record; adjudications differed, an infectious physician provided final adjudication. Positive predictive value for was calculated characteristics cases non-cases were described. Results The 175 individuals. Records available review 139 Among these, 37% (n = 52) classified as confirmed, 17% 24) probable, 45% 63) case. In total, 76 confirmed or probable which available; positive 45%. Cases occurred 28 57 counties City); most (64%) May–September. Median age 60 years (IQR 33 – 73) 67 42 78) (p 0.13); 29% 38% female 0.23). cases, 76% had IgG IgM immunoblots second- third-degree atrioventricular block. Conclusion query, detected carditis, public importance. this may provide useful marker Lyme-endemic states detect changing patterns, including temporal spatial clusters severe manifestations. Disclosures All Authors: No reported disclosures.